Dynamic clamp: a powerful tool in cardiac electrophysiology

Dynamic clamp: a powerful tool in cardiac electrophysiology.

Dynamic clamp is a collection of closely related techniques that have been employed in cardiac electrophysiology to provide direct answers to numerous research questions regarding basic cellular mechanisms of action potential formation, action potential transfer and action potential synchronization in health and disease. Building on traditional current clamp, dynamic clamp was initially used to...

Wilders ‘ Dynamic clamp ’ in cardiac electrophysiology

The voltage clamp and cardiac electrophysiology.

• Although voltage clamp methods have been applied experimentally to cardiac tissue for over a decade, this field of study has failed to achieve general acceptance because of limitations of the experimental approach and difficulty in interpreting the results. Yet this technique is valuable within its limitations, and to dismiss it would be to lose a valuable tool. In perspective, most technique...

Cardiac microdialysis a powerful tool.

See article by Akiyama et al. [1] (pages 531 –538) in [3] reported the application of an existing technique, this issue. microdialysis, to estimate interstitial adenosine and its metabolites. Microdialysis, which evolved during the prior Tsuyoshi Akiyama and Toji Yamazaki have reported decade, had largely been limited to studies evaluating that norepinephrine inhibits acetylcholine release from...

A Powerful Tool for Studying Coronary Circulation and Cardiac Function

With the advent of tissue regeneration and gene therapy for heart disease, evaluation of coronary circulation and cardiac function in vivo, especially in a disease model, is extremely important. Conventional methods such as microcomputed tomography, high-resolution magnetic resonance angiography, and high-resolution ultrasound have become invaluable tools in cardiovascular research. However, th...